Plasmodium vivaxMalaria Relapses after Primaquine Prophylaxis

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Plasmodium vivax Malaria Relapses after Primaquine Prophylaxis

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Primaquine for preventing relapses in people with Plasmodium vivax malaria.

BACKGROUND Plasmodium vivax infections contribute to a significant proportion of the malaria infections in many countries. Primaquine is the most widely used drug for treating the dormant liver stage. Different primaquine dosing regimens are in use. OBJECTIVES To compare primaquine regimens for preventing relapses in people with P. vivax malaria. SEARCH STRATEGY In 2006, we searched the Coc...

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Primaquine and relapses of Plasmodium vivax. Meta analysis of controlled clinical trials.

BACKGROUND Primaquine (PQ) is used against relapses of vivax malaria (RVM) but several aspects about dosage are unknown, as the total effective dose (TD) in a number of days. OBJECTIVE To compare PQ regimens against RVM in randomized or non randomized controlled clinical trials (CCTs). METHODOLOGY Meta analysis. Information was sought until 31 December, 2012 in Lilacs, SciELO, PubMed (Medli...

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Therapeutic efficacy of alternative primaquine regimens to standard treatment in preventing relapses by Plasmodium vivax

OBJECTIVE To compare efficacy and safety of primaquine regimens currently used to prevent relapses by P. vivax. METHODS A systematic review was carried out to identify clinical trials evaluating efficacy and safety to prevent malaria recurrences by P. vivax of primaquine regimen 0.5 mg/kg/ day for 7 or 14 days compared to standard regimen of 0.25 mg/kg/day for 14 days. Efficacy of primaquine ...

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Imported Tertian Malaria Resistant to Primaquine

In Plasmodium vivax and Plasmodium ovale malaria, some of the liver stage parasites remain dormant. The activation of these dormant forms (called hypnozoite) can give rise to relapse weeks, months or years after the initial infection. To prevent relapses, a course of primaquine may be given as terminal prophylaxis to patients. Different strains of Plasmodium vivax vary in their sensitivity to p...

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ژورنال

عنوان ژورنال: Emerging Infectious Diseases

سال: 2006

ISSN: 1080-6040

DOI: 10.3201/eid1211.060613